ISB Researchers Develop New Method to Study and Predict Traits of Cells

A Radically Different Approach to Unraveling Genetic Networks

3 Bullets: ISB researchers used the systems approach to develop a new way to integrate data from different classes of networks to better understand how cells function. The method is a software program called GEMINI and it’s the first of its kind to integrate…

ISB’s PeptideAtlas Helps Advance the Study of Proteins

Human Proteome Project

  3 Bullets The Human Proteome Project expands on the work of the Human Genome Project. ISB is a leader in proteomics and developed PeptideAtlas, a project that has cataloged the proteins observed in thousands of proteomics experiments as an open resource for researchers…

A ‘Sound Check’ for Digital Transcriptomes

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3 Bullets: Looking for biomarkers in different types of tissues requires comparing massive amounts of gene expression data. In order to compare 'digital transcriptome' data, they have to be normalized or adjusted to a common standard of measurement. ISB researchers developed new algorithmic methods…

How ISB’s Systems Approach Finds New Biological Insight from Existing Big-Data Sets

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3 Bullets: There exist copious amounts of public research data that can reveal new biological information if they are integrated and analyzed. One of ISB's specialties is the ability to apply systems approaches to develop methods to integrate and analyze data. In the latest…

Systems Approach to Innovation Helps Extract More Data

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3 Bullets: Technology lag affects the study of proteins, which when quantified can indicate disease or wellness. ISB uses systems approach to innovate and transcend technology limitations. ISB co-develops new technique and software suite to increase protein detection rate. By Dr. Kristian Swearingen Scientific…

New Study: Blood Test Helps Identify Benign Lung Nodules

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Oct. 16, 2013 When it comes to determining whether lung nodules are benign, a patient typically faces surgery and a biopsy. It's an invasive and costly response, and, in 80 percent of cases, unnecessary. But a new study published today in Science Translational Medicine…

New Principle of Chemo-Resistance Sheds Light on Evasiveness of Cancer Cells

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By the Huang Lab Each year more than half a million people in the U.S. die of cancer – the major disease group that has seen the least improvement in cure rate in the past decades. Why is cancer so difficult to treat and…

ISB Analysis May Lead to Earlier Diagnoses of Deadly Brain Tumor

Dr. Nathan Price discusses research with members of his lab group.

By the Price Lab Journal: PLOS ONE Title: Transcriptional Analysis of Aggressiveness and Heterogeneity across Grades of Astrocytomas (link) In a study published on Oct. 11, 2013, in the journal PLOS ONE, ISB researchers present a computational analysis of astrocytoma tumors — including the…

Largest Genetics Catalog of Deadliest Brain Tumor Released

Ilya_PubMM

  By Varsha Dhankani Glioblastoma multiforme (GBM) is the most common and deadliest of malignant primary brain tumors in adults. Because of its lethality, GBM was selected as the first brain tumor to be sequenced as part of The Cancer Genome Atlas (TCGA), a…

New Predictive Model for Methanogenesis: Baliga Lab Published in Genome Research

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By Dr. Nitin Baliga ISB Director Methanogens catalyze the critical, methane-producing step (called methanogenesis) in the anaerobic decomposition of organic matter. Scientists at ISB and University of Washington led a multi-institutional effort to generate the first predictive model for gene regulation of methanogenesis in…